Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine.

Article

Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine.

Cancer research - 1 Apr 1992

Cory J G, Cory A H, Long S D, Carter G L, Johnson C E

Abstract excerpt

L1210 cell lines, selected for resistance to deoxyadenosine due to the loss of allosteric inhibition of ribonucleotide reductase by dATP, had altered steady-state levels of the mRNAs for c-myc, fos, and p53. Wild-type L1210 cells had constitutive steady-state levels of c-myc and p53 with little or no fos mRNA. Two different deoxyadenosine-resistant cell lines (Y8 and ED2) had elevated steady-state levels of c-myc...

Topics

Animals
Blotting, Northern
Blotting, Southern
Cycloheximide
DNA, Neoplasm
Deoxyadenosines
Drug Resistance
Genes, myc
Genes, p53
Genetic Variation
Leukemia L1210

Mice

RNA, Messenger

Restriction Mapping

Transcription, Genetic

Tumor Cells, Cultured

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