Article
Participation of p53 protein in the cellular response to DNA damage.
Cancer research - 1 Dec 1991
Kastan M B, Onyekwere O, Sidransky D, Vogelstein B, Craig R W
Abstract excerpt
The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could contribute to cellular transformation. Exposure of ML-1 myeloblastic leukemia cells to nonlethal doses of the DNA damaging agents, gamma-irradiation or actinomycin D, causes...
Topics
- Bone Marrow Cells
- Caffeine
- Cell Cycle
- Cycloheximide
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Neoplasm
- Dactinomycin
- Exons
- Flow Cytometry
- Genes, p53
- Humans
- Mutation
- Time Factors
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53