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Article

Participation of p53 protein in the cellular response to DNA damage.

Cancer research - 1 Dec 1991

Kastan M B, Onyekwere O, Sidransky D, Vogelstein B, Craig R W

Abstract excerpt

The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could contribute to cellular transformation. Exposure of ML-1 myeloblastic leukemia cells to nonlethal doses of the DNA damaging agents, gamma-irradiation or actinomycin D, causes a transient inhibition of replicative DNA synthesis via both G1 and G2 arrests. Levels of p53 protein in ML-1 cells...

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Identifiers

PMID: 1933891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Participation of p53 protein in the cellular response to DNA damage.PMID 1933891Read ↗

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