An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells.

doi:10.1128/MCB.15.1.290

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Article

An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells.

Molecular and cellular biology - 1 Jan 1995

Vilpo J A, Vilpo L M, Szymkowski D E, O'Donovan A, Wood R D

Abstract excerpt

One of the most widely used antitumor drugs is cis-diamminedichloroplatinum(II) (cisplatin), and mechanisms of cisplatin resistance have been investigated in numerous model systems. Many studies have used mouse leukemia L1210/0 as a reference wild-type cell line, and cisplatin-resistant subclones have been derived from it. Increased DNA excision repair capacity is thought to play a key role in the acquired...

Topics

Animals
Base Sequence
Cisplatin
DNA
DNA Damage
DNA Primers
DNA Repair
DNA-Binding Proteins
Drug Resistance
Endonucleases
Gene Expression
Leukemia L1210

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Nuclear Proteins

RNA, Messenger

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 7799936
DOI: 10.1128/MCB.15.1.290
PMCID: PMC231955

Genes

ERCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7799936-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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