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Article

Differential induction of apoptosis in x-irradiated L5178Y sublines bearing p53 mutation.

Radiation and environmental biophysics - 1 Mar 2000

Szumiel I, Jaworska A, Kapiszewska M, John A, Gradzka I, Sochanowicz B

Abstract excerpt

We examined apoptosis and expression of p53, E2F-1, bax, bclx(L) and bc12 proteins in two L5178Y (LY) murine lymphoma sublines, LY-R and LY-S, which differ in radiosensitivity and double-strand break (DSB) repair. Both sublines are heterozygous for a p53 mutation in codon 170 that precludes the transactivation function. Accordingly, there is no G1/S arrest after irradiation. We found that there is no change in...

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PMID: 10789893
DOI: 10.1007/pl00007684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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