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Article

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Journal of the American Society of Nephrology : JASN - 1 Jan 2013

Manning Danielle K, Sergeev Mikhail, van Heesbeen Roy G, Wong Michael D, Oh Jin-Hee, Liu Yan, Henkelman R Mark, Drummond Iain, Shah Jagesh V, Beier David R

Abstract excerpt

A missense mutation in mouse Nek8, which encodes a ciliary kinase, produces the juvenile cystic kidneys (jck) model of polycystic kidney disease, but the functions of Nek8 are incompletely understood. Here, we generated a Nek8-null allele and found that homozygous mutant mice die at birth and exhibit randomization of left-right asymmetry, cardiac anomalies, and glomerular kidney cysts. The requirement for Nek8 in...

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Source

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Identifiers

PMID: 23274954
DOI: 10.1681/ASN.2012050490
PMCID: PMC3537214

Genes

NEK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.PMID 23274954Read ↗

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression.Semantic proximity Read ↗

The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.Semantic proximity Read ↗

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.Semantic proximity Read ↗

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.Semantic proximity Read ↗

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Semantic proximity Read ↗

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.Semantic proximity Read ↗

Defects in ciliary localization of Nek8 is associated with cystogenesis.Semantic proximity Read ↗

Dynein axonemal intermediate chain 2 is required for formation of the left-right body axis and kidney in medaka.Semantic proximity Read ↗

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis.Semantic proximity Read ↗

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry.Semantic proximity Read ↗

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.Semantic proximity Read ↗

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.Semantic proximity Read ↗

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