Article

Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function

2020-07-01

Abstract excerpt

<h4>Background</h4> Kinesin family member 3A (KIF3A) is a molecular motor protein in the heterotrimeric kinesin-2 complex that drives anterograde intraflagellar transport. This process plays a pivotal role in both biogenesis and maintenance of the primary cilium that supports tissue development. Ciliogenesis associated kinase 1 (CILK1) phosphorylates human KIF3A at Thr672. CILK1 loss of function causes ciliopathi...

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Literature Corpus work: eadc9a01-17ad-543c-8116-4eb476fbc5f9
DOI: 10.1101/2020.06.30.180307

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