Article
PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation.
Development (Cambridge, England) - 1 Jun 2009
Yen Wei Wei, Williams Margot, Periasamy Ammasi, Conaway Mark, Burdsal Carol, Keller Raymond, Lu Xiaowei, Sutherland Ann
Abstract excerpt
Despite being implicated as a mechanism driving gastrulation and body axis elongation in mouse embryos, the cellular mechanisms underlying mammalian convergent extension (CE) are unknown. Here we show, with high-resolution time-lapse imaging of living mouse embryos, that mesodermal CE occurs by mediolateral cell intercalation, driven by mediolaterally polarized cell behavior. The initial events in the onset of CE...
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