Article
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
Science (New York, N.Y.) - 12 Oct 2012
Yoshiba Satoko, Shiratori Hidetaka, Kuo Ivana Y, Kawasumi Aiko, Shinohara Kyosuke, Nonaka Shigenori, Asai Yasuko, Sasaki Genta, Belo Jose Antonio, Sasaki Hiroshi, Nakai Junichi, Dworniczak Bernd, Ehrlich Barbara E, Pennekamp Petra, Hamada Hiroshi
Abstract excerpt
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca(2+) channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the nodal flow. Examination of mutant forms of Pkd2 shows that the ciliary localization of Pkd2 is essential for...
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