Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism.

doi:10.1093/emboj/18.7.1974

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Article

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism.

The EMBO journal - 1 Apr 1999

Eaglestone S S, Cox B S, Tuite M F

Abstract excerpt

[PSI+] is a protein-based heritable phenotype of the yeast Saccharomyces cerevisiae which reflects the prion-like behaviour of the endogenous Sup35p protein release factor. [PSI+] strains exhibit a marked decrease in translation termination efficiency, which permits decoding of translation termination signals and, presumably, the production of abnormally extended polypeptides. We have examined whether the...

Topics

Fungal Proteins
Genes, Fungal
Hot Temperature
Models, Biological
Peptide Termination Factors
Phenotype
Prions
Protein Biosynthesis
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Suppression, Genetic

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Identifiers

PMID: 10202160
DOI: 10.1093/emboj/18.7.1974
PMCID: PMC1171282

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