Article
A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.
PloS one - 1 Jan 2017
Wang Kai, Melki Ronald, Kabani Mehdi
Abstract excerpt
Self-replicating 'proteinaceous infectious particles' or prions are responsible for complex heritable traits in the yeast Saccharomyces cerevisiae. Our current understanding of the biology of yeast prions stems from studies mostly done in the context of actively dividing cells in optimal laboratory growth conditions. Evidence suggest that fungal prions exist in the wild where most cells are in a non-dividing...
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