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Article

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits.

Nature - 9 Sept 2004

True Heather L, Berlin Ilana, Lindquist Susan L

Abstract excerpt

Phenotypic plasticity and the exposure of hidden genetic variation both affect the survival and evolution of new traits, but their contributing molecular mechanisms are largely unknown. A single factor, the yeast prion [PSI(+)], may exert a profound effect on both. [PSI(+)] is a conserved, protein-based genetic element that is formed by a change in the conformation and function of the translation termination...

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Identifiers

PMID: 15311209
DOI: 10.1038/nature02885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits.PMID 15311209Read ↗

A yeast prion provides a mechanism for genetic variation and phenotypic diversity.Semantic proximity Read ↗

Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+].Semantic proximity Read ↗

Prions are a common mechanism for phenotypic inheritance in wild yeasts.Semantic proximity Read ↗

Prion switching in response to environmental stress.Semantic proximity Read ↗

Epigenetic control of polyamines by the prion [PSI+].Semantic proximity Read ↗

The [PSI+] prion exists as a dynamic cloud of variants.Semantic proximity Read ↗

Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation.Semantic proximity Read ↗

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.Semantic proximity Read ↗

Prion protein remodelling confers an immediate phenotypic switch.Semantic proximity Read ↗

Prions as Protein-Based Genetic ElementsSemantic proximity Read ↗

Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes.Semantic proximity Read ↗

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism.Semantic proximity Read ↗

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