Article
Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes.
PloS one - 1 Jan 2011
Fitzpatrick David A, O'Brien Jennifer, Moran Ciara, Hasin Naushaba, Kenny Elaine, Cormican Paul, Gates Amy, Morris Derek W, Jones Gary W
Abstract excerpt
The yeast prion [PSI(+)] has been implicated in the generation of novel phenotypes by a mechanism involving a reduction in translation fidelity causing readthrough of naturally occurring stop codons. Some [PSI(+)] associated phenotypes may also be generated due to readthrough of inactivating stop codon mutations (ISCMs). Using next generation sequencing we have sequenced the genomes of two Saccharomyces...
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