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Article

Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+].

Molecular biology of the cell - 1 Apr 2009

Strawn Lisa A, Lin Changyi A, Tank Elizabeth M H, Osman Morwan M, Simpson Sarah A, True Heather L

Abstract excerpt

The yeast [PSI+] prion is an epigenetic modifier of translation termination fidelity that causes nonsense suppression. The prion [PSI+] forms when the translation termination factor Sup35p adopts a self-propagating conformation. The presence of the [PSI+] prion modulates survivability in a variety of growth conditions. Nonsense suppression is essential for many [PSI+]-mediated phenotypes, but many do not appear...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19225160
DOI: 10.1091/mbc.e08-08-0813
PMCID: PMC2669030

Genes

CTR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+].PMID 19225160Read ↗

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits.Semantic proximity Read ↗

Epigenetic control of polyamines by the prion [PSI+].Semantic proximity Read ↗

A yeast prion provides a mechanism for genetic variation and phenotypic diversity.Semantic proximity Read ↗

Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation.Semantic proximity Read ↗

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism.Semantic proximity Read ↗

The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae.Semantic proximity Read ↗

Detection system- and strain-dependent diversity of de novo [PSI+] prion generation and phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.Semantic proximity Read ↗

An engineered nonsense URA3 allele provides a versatile system to detect the presence, absence and appearance of the [PSI+] prion in Saccharomyces cerevisiae.Semantic proximity Read ↗

The [PSI+] prion exists as a dynamic cloud of variants.Semantic proximity Read ↗

Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes.Semantic proximity Read ↗

Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.Semantic proximity Read ↗

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