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Article

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.

The EMBO journal - 17 Jun 1996

Paushkin S V, Kushnirov V V, Smirnov V N, Ter-Avanesyan M D

Abstract excerpt

The Sup35p protein of yeast Saccharomyces cerevisiae is a homologue of the polypeptide chain release factor 3 (eRF3) of higher eukaryotes. It has been suggested that this protein may adopt a specific self-propagating conformation, similar to mammalian prions, giving rise to the [psi+] nonsense suppressor determinant, inherited in a non-Mendelian fashion. Here we present data confirming the prion-like nature of...

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PMID: 8670813
PMCID: PMC450255

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Research trail→

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Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.PMID 8670813Read ↗

Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.Semantic proximity Read ↗

Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation.Semantic proximity Read ↗

Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation.Semantic proximity Read ↗

[Fusion of glutathione S-transferase with the N-terminus of yeast Sup35p protein inhibits its prion-like properties].Semantic proximity Read ↗

The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3.Semantic proximity Read ↗

The [PSI+] prion of yeast: a problem of inheritance.Semantic proximity Read ↗

The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants.Semantic proximity Read ↗

[Modification of [PSI+] prion properties by the combination of amino acid changes within Sup35 protein N-domain].Semantic proximity Read ↗

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae.Semantic proximity Read ↗

In vitro propagation of the prion-like state of yeast Sup35 protein.Semantic proximity Read ↗

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].Semantic proximity Read ↗

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.Semantic proximity Read ↗

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