Article
Epigenetic control of polyamines by the prion [PSI+].
Nature cell biology - 1 Sept 2008
Namy Olivier, Galopier Aurélie, Martini Cyrielle, Matsufuji Senya, Fabret Céline, Rousset Jean-Pierre
Abstract excerpt
Prion proteins are found in mammals and yeast, and can transmit diseases and encode heritable phenotypic traits. In Saccharomyces cerevisiae, eRF3, Rnq1, Ure2 and Swil are functional proteins with a soluble conformation that can switch to a non-functional, amyloid conformation denoted as [PSI+], [PIN+], [URE3] and [SWI+], respectively. The prion [PSI+] corresponds to an aggregated conformation of the...
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