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Article

FHITness and cancer.

Oncology research - 1 Jan 1998

Druck T, Berk L, Huebner K

Abstract excerpt

In early 1996, the Fragile Histidine Triad or FHIT gene (pronounced FIT) was cloned and shown to straddle the most fragile human chromosome site at chromosome band 3p14.2. The exceptionally large FHIT locus also encompasses a hereditary renal carcinoma associated chromosome translocation breakpoint and is very frequently altered by internal deletions in the most common human cancers. Germline alteration of one...

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Source

Identifiers

PMID: 10063967

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FHITness and cancer.PMID 10063967Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

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Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.Semantic proximity Read ↗

Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.Semantic proximity Read ↗

FRA3B and other common fragile sites: the weakest links.Semantic proximity Read ↗

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activitySemantic proximity Read ↗

Fragile histidine triad protein: structure, function, and its association with tumorogenesis.Semantic proximity Read ↗

FHIT alterations in breast cancer.Semantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

Replacement of Fhit in cancer cells suppresses tumorigenicity.Semantic proximity Read ↗

Large common fragile site genes and cancer.Semantic proximity Read ↗

Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea.Semantic proximity Read ↗

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