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Article

Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea.

World journal of gastroenterology - 14 Jun 2008

Nam Chang-Woo, Shin Jung-Woo, Park Neung-Hwa

Abstract excerpt

AIM: To establish the role of FHIT in the pathogenesis hepatocellular carcinoma (HCC). METHODS: We examined genomic alterations, as well as, mRNA and protein expression patterns from the FHIT gene, in 48 surgically resected hepatocellular carcinoma (HCC) tissues. Additionally, p53 mutations were analyzed. RESULTS: Aberrant FHIT transcripts were detected in 11 of 48 surrounding non-tumor liver tissues and 27 of 48...

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Share to Acid Anhydride Hydrolases
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Loss of Heterozygosity

Share to Neoplasm Proteins

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 18567082
DOI: 10.3748/wjg.14.3526
PMCID: PMC2716616

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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