Article
Replacement of Fhit in cancer cells suppresses tumorigenicity.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Siprashvili Z, Sozzi G, Barnes L D, McCue P, Robinson A K, Eryomin V, Sard L, Tagliabue E, Greco A, Fusetti L, Schwartz G, Pierotti M A, Croce C M, Huebner K
Abstract excerpt
The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions. Fhit hydrolyzes dinucleotide 5',5"'-P1,P3-triphosphate in vitro and mutation of a central histidi...
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