Article
Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.
Cancer genetics and cytogenetics - 1 May 2000
Menin C, Santacatterina M, Zambon A, Montagna M, Parenti A, Ruol A, D'Andrea E
Abstract excerpt
The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile site FRA3B. Even though its role in carcinogenesis is still unclear, this gene is frequently inactivated by carcinogen-induced intragenic deletions in many types of cancers, and FHIT abnormal transcripts are found in many primary tumors and tumor-derived cell lines. We evaluated FHIT gene involvement in 39...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.