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Article

FHIT alterations in breast cancer.

Seminars in cancer biology - 1 Oct 2001

Ingvarsson S

Abstract excerpt

The FHIT gene encodes a diadenosine hydrolase and may be involved in growth control pathways of the cell. Studies on protein-protein interactions, cell lines, including tumourigenicity tests, and knockout mice suggest that the Fhit protein is involved in cell proliferation and apoptosis, and might act as a tumour suppressor. In several different cancers, including breast cancer, alterations in the FHIT gene have...

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Source

Identifiers

PMID: 11562178
DOI: 10.1006/scbi.2001.0391

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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FHIT alterations in breast cancer.PMID 11562178Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

The expression of Fhit protein is related inversely to disease progression in patients with breast carcinomaSemantic proximity Read ↗

Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers.Semantic proximity Read ↗

FHITness and cancer.Semantic proximity Read ↗

fhit Alterations in endometrial carcinoma and hyperplasia.Semantic proximity Read ↗

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activitySemantic proximity Read ↗

Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir.Semantic proximity Read ↗

Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix.Semantic proximity Read ↗

Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas.Semantic proximity Read ↗

Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.Semantic proximity Read ↗

Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.Semantic proximity Read ↗

FHA Domains as Phospho‐Threonine Binding Modules in Cell SignalingSemantic proximity Read ↗

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