Article
Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.
Current gene therapy - 1 Mar 2004
Ishii Hideshi, Vecchione Andrea, Fong Louise Y Y, Zanesi Nicola, Trapasso Francesco, Furukawa Yusuke, Baffa Raffaele, Huebner Kay, Croce Carlo M
Abstract excerpt
A link between common chromosome fragile sites and frequent chromosomal deletions in cancer was observed two decades ago and led to the hypothesis that genes at fragile sites may play a role in tumor development. In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2. Loss or...
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