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Article

Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.

Current gene therapy - 1 Mar 2004

Ishii Hideshi, Vecchione Andrea, Fong Louise Y Y, Zanesi Nicola, Trapasso Francesco, Furukawa Yusuke, Baffa Raffaele, Huebner Kay, Croce Carlo M

Abstract excerpt

A link between common chromosome fragile sites and frequent chromosomal deletions in cancer was observed two decades ago and led to the hypothesis that genes at fragile sites may play a role in tumor development. In 1996, the human fragile histidine triad gene, FHIT, was identified by positional...

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Source

Identifiers

PMID: 15032614
DOI: 10.2174/1566523044578031

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15032614-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.PMID 15032614Read ↗

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Influence of a nonfragile FHIT transgene on murine tumor susceptibility.Semantic proximity Read ↗

The role of the FHIT/FRA3B locus in cancer.Semantic proximity Read ↗

Common fragile genes and digestive tract cancers.Semantic proximity Read ↗

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.Semantic proximity Read ↗

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