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Article

Large common fragile site genes and cancer.

Seminars in cancer biology - 1 Feb 2007

Smith David I, McAvoy Sarah, Zhu Yu, Perez Damon S

Abstract excerpt

The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the...

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Source

Identifiers

PMID: 17140807
DOI: 10.1016/j.semcancer.2006.10.003

Genes

FHIT
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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