Article
Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers.
Cytogenetic and genome research - 1 Jan 2016
Karras Jenna R, Schrock Morgan S, Batar Bahadir, Huebner Kay
Abstract excerpt
FHIT, located at FRA3B, is one of the most commonly deleted genes in human cancers, and loss of FHIT protein is one of the earliest events in cancer initiation. However, location of FHIT at a chromosomal fragile site, a locus prone to breakage and gap formation under even mild replication stress, has encouraged claims that FHIT loss is a passenger event in cancers. We summarize accumulated evidence that FHIT...
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