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Article

Fragile histidine triad protein: structure, function, and its association with tumorogenesis.

Journal of cancer research and clinical oncology - 1 Mar 2010

Hassan Md Imtaiyaz, Naiyer Abdullah, Ahmad Faizan

Abstract excerpt

BACKGROUND: The human fragile histidine triad (FHIT) gene is a putative tumor suppressor gene, which is located at chromosome region 3p14.2. It was suggested that the loss of heterozygosity (LOH), homozygous deletions, and abnormal expression of the FHIT gene were involved in several types of human malignancies. MATERIALS AND METHODS: To determine the role of FHIT in various cancers, we have performed structural...

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Identifiers

PMID: 20033706
DOI: 10.1007/s00432-009-0751-9

Genes

FHIT

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Related research

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Research trail→

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Fragile histidine triad protein: structure, function, and its association with tumorogenesis.PMID 20033706Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

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FHITness and cancer.Semantic proximity Read ↗

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Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.Semantic proximity Read ↗

Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy.Semantic proximity Read ↗

[Association of fragile histidine triad gene (FHIT) with susceptibility to esophageal cancer. A preliminary study].Semantic proximity Read ↗

Impact of FHIT loss on the translation of cancer-associated mRNAs.Semantic proximity Read ↗

[Mutations of fragile histidine triad gene in Peutz-Jeghers syndrome and canceration].Semantic proximity Read ↗

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activitySemantic proximity Read ↗

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