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Article

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.

Molecular medicine (Cambridge, Mass.) - 1 Jul 2001

Pavelić K, Krizanac S, Cacev T, Hadzija M P, Radosević S, Crnić I, Levanat S, Kapitanović S

Abstract excerpt

BACKGROUND: Human FHIT (fragile histidine triad) gene is highly conserved gene homologous to a group of genes identified in prokaryotes and eukaryotes. Loss of FHIT function may be important in the development and/or progression of various types of cancer. MATERIALS AND METHODS: We undertook a clinical study to analyze the relation between aberrant function of FHIT gene, tumor cell proliferation, and intensity of...

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Source

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Identifiers

PMID: 11683369
PMCID: PMC1950052

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.PMID 11683369Read ↗

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Mutation and abnormal expression of the fragile histidine triad gene in nasopharyngeal carcinoma.Semantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lungSemantic proximity Read ↗

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.Semantic proximity Read ↗

[Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549].Semantic proximity Read ↗

Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.Semantic proximity Read ↗

Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.Semantic proximity Read ↗

FHITness and cancer.Semantic proximity Read ↗

[Ectogenous fragile histidine triad gene inhibits the malignant phenotype of human lung cancer cell line A549 in vitro and in vivo].Semantic proximity Read ↗

Restoration of fragile histidine triad ( <i>FHIT</i> ) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell linesSemantic proximity Read ↗

[Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes].Semantic proximity Read ↗

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