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The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activity

10 Dec 2007

Abstract excerpt

The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors. Fhit was classified as a tumor suppressor; however, the molecular mechanisms of its function are not well established. Here, we report that Fhit associates with the...

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PMID: 18077326
DOI: 10.1073/pnas.0703664105

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