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Article

Do FHIT gene alterations play a role in human solid tumors?

Asia-Pacific journal of clinical oncology - 1 Oct 2018

Silveira Zavalhia Lisiane, Weber Medeiros Aline, Oliveira Silva Andrew, Vial Roehe Adriana

Abstract excerpt

The fragile histidine triad (FHIT) gene encloses an active common chromosomal fragile site, FRA3B. This gene is known to be associated with genomic instability, apoptosis and DNA damage. FHIT disturbances have been related to carcinogenesis in different types of human tumor. Despite this, there are some controversies about the exact role of the FHIT gene in relation to tumor biology. Several pieces of evidence...

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Identifiers

PMID: 29516675
DOI: 10.1111/ajco.12868

Genes

FHIT

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