Article

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

2023-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic regulation of gene expression is fundamental to cell state transitions. A prominent example of this is the epigenetically-regulated generation of transitory cells states within the germinal center (GC) reaction that are required for humoral immunity. The deregulation of these processes through somatic mutations can give rise to B-cell lymphoma, thus studying these mutations can provid...

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Literature Corpus work: ffb01db6-40e6-55a3-b310-10947ffdb14a
DOI: 10.1101/2023.09.05.556242

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CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancyDOI 10.1101/2023.09.05.556242Read

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