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Article

Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement.

Blood - 10 Jul 2025

Yang Haopeng, Zhang Wenchao, Ravanmehr Vida, Cui Guiling, Bowman Kevin, Chen Ruidong, Henderson Jared M, Lockman Shyanne, Rojas Estela, Wilson Ashley, Parsons Sydney, Mechaly Ariel, Regad Leslie, Haouz Ahmed, Flowers Christopher R, Neelapu Sattva, Nastoupil Loretta, Davis R Eric, Deng Qing, Rodrigues-Lima Fernando, Green Michael R

Abstract excerpt

ABSTRACT: The CREBBP lysine acetyltransferase (KAT) is frequently mutated in follicular lymphoma and diffuse large B-cell lymphoma and has been studied using gene knockout in murine and human cells. However, most CREBBP mutations encode amino acid substitutions within the catalytic KAT domain (CREBBP KAT-PM) that retain an inactive protein and have not been extensively characterized. Using CRISPR gene editing and...

Read the complete abstract on PubMed

Topics

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Share to Acetylation
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD40 Antigens

Share to CREB-Binding Protein

Share to E1A-Associated p300 Protein

Share to Enhancer Elements, Genetic

Share to Lymphoma

Share to Lymphoma, Large B-Cell, Diffuse

Source

Open in PubMed Open full text

Identifiers

PMID: 40090010
DOI: 10.1182/blood.2024026664
PMCID: PMC12333230

Genes

CREBBP
CD40
CD4
TF
EP300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement.PMID 40090010Read ↗

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