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Article

Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Nature - 10 Mar 2011

Pasqualucci Laura, Dominguez-Sola David, Chiarenza Annalisa, Fabbri Giulia, Grunn Adina, Trifonov Vladimir, Kasper Lawryn H, Lerach Stephanie, Tang Hongyan, Ma Jing, Rossi Davide, Chadburn Amy, Murty Vundavalli V, Mullighan Charles G, Gaidano Gianluca, Rabadan Raul, Brindle Paul K, Dalla-Favera Riccardo

Abstract excerpt

B-cell non-Hodgkin's lymphoma comprises biologically and clinically distinct diseases the pathogenesis of which is associated with genetic lesions affecting oncogenes and tumour-suppressor genes. We report here that the two most common types--follicular lymphoma and diffuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rarely, EP300, two highly related histone and...

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Topics

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Share to Acetyl Coenzyme A
Share to Acetyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CREB-Binding Protein

Share to E1A-Associated p300 Protein

Share to Histone Acetyltransferases

Share to Lymphoma, B-Cell

Share to Lymphoma, Follicular

Share to Proto-Oncogene Proteins c-bcl-6

Source

Open in PubMed Open full text

Identifiers

PMID: 21390126
DOI: 10.1038/nature09730
PMCID: PMC3271441

Genes

CREBBP
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Inactivating mutations of acetyltransferase genes in B-cell lymphoma.PMID 21390126Read ↗

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