Article
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2023
Vlasevska Sofija, Garcia-Ibanez Laura, Duval Romain, Holmes Antony B, Jahan Rahat, Cai Bowen, Kim Andrew, Mo Tongwei, Basso Katia, Soni Rajesh K, Bhagat Govind, Dalla-Favera Riccardo, Pasqualucci Laura
Abstract excerpt
Heterozygous inactivating mutations of the KMT2D methyltransferase and the CREBBP acetyltransferase are among the most common genetic alterations in B cell lymphoma and co-occur in 40 to 60% of follicular lymphoma (FL) and 30% of EZB/C3 diffuse large B cell lymphoma (DLBCL) cases, suggesting they may be coselected. Here, we show that combined germinal center (GC)-specific haploinsufficiency of Crebbp and Kmt2d...
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