Article

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

2020-01-15

Abstract excerpt

<h4>Background: </h4> Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD. To elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau, numerous transgenic mouse models that recapitulate critical AD-like pathology have been de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a5e3357-8634-5bdb-a6db-2ba0b85a3ced
DOI: 10.21203/rs.2.17631/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s diseaseDOI 10.21203/rs.2.17631/v2Read

Sexual dimorphism in behavior, neuropathology, and biomarkers in a tau P301S mouse model of Alzheimer’s diseaseSemantic proximity Read

Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice – A Model for TauopathySemantic proximity Read

Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male miceSemantic proximity Read

Age, Sex and Alzheimer’s disease: A longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patientsSemantic proximity Read

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.Semantic proximity Read

Single <i>MAPT</i> knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research communitySemantic proximity Read

Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice.Semantic proximity Read

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Semantic proximity Read

Sex differences in behaviour and molecular pathology in the 5XFAD modelSemantic proximity Read

Common mouse models of tauopathy reflect early but not late human diseaseSemantic proximity Read

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.Semantic proximity Read

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.Semantic proximity Read