Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.

Neurobiology of aging - 1 Dec 2015

Jiang Teng, Tan Lan, Zhu Xi-Chen, Zhou Jun-Shan, Cao Lei, Tan Meng-Shan, Wang Hui-Fu, Chen Qi, Zhang Ying-Dong, Yu Jin-Tai

Abstract excerpt

Tau pathology is a pathological hallmark for several neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia. As a novel susceptibility gene for these 2 diseases, triggering receptor expressed on myeloid cells 2 (TREM2) gene encodes an immune receptor that is uniquely expressed by microglia. Recently, a correlation between TREM2 expression and hyperphosphorylated tau has been revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Silencing
Share to Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C3H

Share to Microglia

Share to Nerve Degeneration

Share to Receptors, Immunologic

Share to Tauopathies

Share to Up-Regulation

Source

Identifiers

PMID: 26364736
DOI: 10.1016/j.neurobiolaging.2015.08.019

Genes

TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.PMID 26364736Read ↗

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.Semantic proximity Read ↗

THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiencySemantic proximity Read ↗

The role of TREM2 in Alzheimer’s disease: from the perspective of TauSemantic proximity Read ↗

Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.Semantic proximity Read ↗

Soluble TREM2 induces inflammatory responses and enhances microglial survival.Semantic proximity Read ↗

TREM2 limits progression of deficits and spreading of tau pathology in miceSemantic proximity Read ↗

Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.Semantic proximity Read ↗

Activated microglia mitigate Aβ-associated tau seeding and spreading.Semantic proximity Read ↗

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.Semantic proximity Read ↗

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.Semantic proximity Read ↗

Sustained TREM2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.