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Article

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.

Neuropharmacology - 1 Jun 2016

Jiang Teng, Zhang Ying-Dong, Chen Qi, Gao Qing, Zhu Xi-Chen, Zhou Jun-Shan, Shi Jian-Quan, Lu Huan, Tan Lan, Yu Jin-Tai

Abstract excerpt

As a novel risk gene for Alzheimer's disease (AD), triggering receptor expressed on myeloid cells 2 (TREM2) gene encodes a type I transmembrane receptor that is uniquely expressed by the microglia in the brain. Emerging evidence indicates a strong association between TREM2 and tau pathology in the cerebral spinal fluid or brain tissue of AD patients. In line with these clinical findings, we found that TREM2 was...

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Identifiers

PMID: 26802771
DOI: 10.1016/j.neuropharm.2016.01.028

Genes

TREM2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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