Article

GxE PRS: Genotype-environment interaction in polygenic risk score models for quantitative and binary traits

2023-07-21

Abstract excerpt

The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual’s genetic profile. However, the impact of genotype-environment interaction (GxE) on the performance and applicability of PRS models remains a crucial aspect to be explored. Currently, existing GxE PRS models are often inappropriately used, which can res...

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Literature Corpus work: ffa86e8e-b30e-57b3-9721-bcc37c2fe6f1
DOI: 10.1101/2023.07.20.549816

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