Article

Reimagining Gene-Environment Interaction Analysis for Human Complex Traits

2022-12-14

Abstract excerpt

In this study, we introduce PIGEON—a novel statistical framework for quantifying and estimating polygenic gene-environment interaction (GxE) using a variance component analytical approach. Based on PIGEON, we outline the main objectives in GxE studies, demonstrate the flaws in existing GxE approaches, and introduce an innovative estimation procedure which only requires summary statistics as input. We demonstrate t...

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Literature Corpus work: 430013da-bac0-5c3f-af0c-5e01c8ab00ff
DOI: 10.1101/2022.12.11.519973

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