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Mitigating type 1 error inflation and power loss in GxE PRS: Genotype-environment interaction in polygenic risk score models.

Genetic epidemiology - 1 Mar 2024

Jayasinghe Dovini, Momin Md Moksedul, Beckmann Kerri, Hyppönen Elina, Benyamin Beben, Lee S Hong

Abstract excerpt

The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual's genetic profile. However, the impact of genotype-environment interaction (GxE) on the performance and applicability of PRS models remains a crucial aspect to be explored. Currently, existing genotype-environment interaction polygenic risk score (GxE...

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PMID: 38303123
DOI: 10.1002/gepi.22546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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