Article

Gene-environment interactions using a Bayesian whole genome regression model

2019-10-09

Abstract excerpt

The contribution of gene-environment (GxE) interactions for many human traits and diseases is poorly characterised. We propose a Bayesian whole genome regression model, LEMMA, for joint modeling of main genetic effects and gene-environment interactions in large scale datasets such as the UK Biobank, where many environmental variables have been measured. The method estimates a linear combination of environmental va...

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Literature Corpus work: b07c011f-4e38-5b9e-9e44-70041dd05655
DOI: 10.1101/797829

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