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Article

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits.

American journal of human genetics - 11 Jul 2024

Pazokitoroudi Ali, Liu Zhengtong, Dahl Andrew, Zaitlen Noah, Rosset Saharon, Sankararaman Sriram

Abstract excerpt

Understanding the contribution of gene-environment interactions (GxE) to complex trait variation can provide insights into disease mechanisms, explain sources of heritability, and improve genetic risk prediction. While large biobanks with genetic and deep phenotypic data hold promise for obtaining novel insights into GxE, our understanding of GxE architecture in complex traits remains limited. We introduce a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38866020
DOI: 10.1016/j.ajhg.2024.05.015
PMCID: PMC11267529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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