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Analyzing Complex Traits and Diseases using GxE PRS: Genotype-Environment Interaction in Polygenic Risk Score Models

2024-12-12

Abstract excerpt

<title>Abstract</title> <p>A deeper understanding of how environmental factors influence genetic risks is crucial for exploring their combined effects on health outcomes. This can be effectively achieved by incorporating genotype-environment (GxE) interactions in polygenic risk score (PRS) models. We applied our recently developed GxEprs model to a wide range of obesity-related complex traits and diseases, levera...

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Literature Corpus work: f991c3b7-b7df-5c95-b802-1277f8dd197e
DOI: 10.21203/rs.3.rs-5576384/v1

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