Article
Quantification of the overall contribution of gene-environment interaction for obesity-related traits.
Nature communications - 13 Mar 2020
Sulc Jonathan, Mounier Ninon, Günther Felix, Winkler Thomas, Wood Andrew R, Frayling Timothy M, Heid Iris M, Robinson Matthew R, Kutalik Zoltán
Abstract excerpt
The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to continuous traits taking into account all interacting environmental variables, without the need to measure any. Extensive simulations demonstrate that our method provides unbiased interaction estimates...
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