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Anti-VEGF vascular remodeling drives germinal center B cell-rich tertiary lymphoid structures during antibody-toxin and anti-CD40 combination therapy in glioblastoma

2026-04-17

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is characterized by aberrant neovascularization and angiogenesis. Bevacizumab (Avastin), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is clinically used with chemotherapy for patients with GBM, yet its impact on the tumor immune microenvironment remains poorly understood. Transcriptomic profiling of matched pre- and post-treatment tumors...

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Literature Corpus work
ff7331e3-1145-5db5-b031-d055bfcb447a
DOI
10.21203/rs.3.rs-9350019/v1
Open publication

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Anti-VEGF vascular remodeling drives germinal center B cell-rich tertiary lymphoid structures during antibody-toxin and anti-CD40 combination therapy in glioblastomaDOI 10.21203/rs.3.rs-9350019/v1
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