Article
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma.
Cancer cell - 12 Jun 2023
Ramachandran Mohanraj, Vaccaro Alessandra, van de Walle Tiarne, Georganaki Maria, Lugano Roberta, Vemuri Kalyani, Kourougkiaouri Despoina, Vazaios Konstantinos, Hedlund Marie, Tsaridou Georgia, Uhrbom Lene, Pietilä Ilkka, Martikainen Miika, van Hooren Luuk, Olsson Bontell Thomas, Jakola Asgeir S, Yu Di, Westermark Bengt, Essand Magnus, Dimberg Anna
Abstract excerpt
Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T cell infiltration. LIGHT/TNFSF14 can induce high endothelial venules (HEVs) and tertiary lymphoid structures (TLS), suggesting that its therapeutic expression could promote T cell recruitment. Here, we use a brain endothelial...
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