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Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

2021-12-24

Abstract excerpt

<h4>Summary</h4> The lack of T-cell infiltrates is a major obstacle to effective immunotherapy in cancer. Conversely, the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLS), which are the local site of humoral and cellular immune responses against cancers, are associated with good prognosis and have recently been detected in Immune Checkpoint Blockade (ICB)-responding patients. However, how...

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Literature Corpus work
975f7f28-7dd3-5653-9bc3-387800fed79b
DOI
10.1101/2021.12.24.474088
Open publication

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Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loopDOI 10.1101/2021.12.24.474088
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