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Article

Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules.

The Journal of pathology - 1 Jun 2018

He Bo, Jabouille Arnaud, Steri Veronica, Johansson-Percival Anna, Michael Iacovos P, Kotamraju Venkata Ramana, Junckerstorff Reimar, Nowak Anna K, Hamzah Juliana, Lee Gabriel, Bergers Gabriele, Ganss Ruth

Abstract excerpt

High-grade brain cancer such as glioblastoma (GBM) remains an incurable disease. A common feature of GBM is the angiogenic vasculature, which can be targeted with selected peptides for payload delivery. We assessed the ability of micelle-tagged, vascular homing peptides RGR, CGKRK and NGR to specifically bind to blood vessels in syngeneic orthotopic GBM models. By using the peptide CGKRK to deliver the tumour...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29603739
DOI: 10.1002/path.5080
PMCID: PMC6737176

Genes

RGR
TNF
TNFSF14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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