Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.

Nature communications - 5 Jul 2021

van Hooren Luuk, Vaccaro Alessandra, Ramachandran Mohanraj, Vazaios Konstantinos, Libard Sylwia, van de Walle Tiarne, Georganaki Maria, Huang Hua, Pietilä Ilkka, Lau Joey, Ulvmar Maria H, Karlsson Mikael C I, Zetterling Maria, Mangsbo Sara M, Jakola Asgeir S, Olsson Bontell Thomas, Smits Anja, Essand Magnus, Dimberg Anna

Abstract excerpt

Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to CD11b Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD40 Antigens

Share to Glioma

Share to Immunoglobulin G

Share to Immunotherapy

Share to Myeloid Cells

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34226552
DOI: 10.1038/s41467-021-24347-7
PMCID: PMC8257767

Genes

CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.PMID 34226552Read ↗

Glioma-associated tertiary lymphoid structures are sites of lymphocyte clonal expansion and plasma cell formationSemantic proximity Read ↗

Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastomaSemantic proximity Read ↗

Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcomeSemantic proximity Read ↗

Anti-VEGF vascular remodeling drives germinal center B cell-rich tertiary lymphoid structures during antibody-toxin and anti-CD40 combination therapy in glioblastomaSemantic proximity Read ↗

Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy.Semantic proximity Read ↗

B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?Semantic proximity Read ↗

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.Semantic proximity Read ↗

Characterization of tumour interactions with the immune system in an autochthonous mouse model of glioblastomaSemantic proximity Read ↗

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironmentSemantic proximity Read ↗

Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40Semantic proximity Read ↗

CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastomaSemantic proximity Read ↗

Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.