Article

Distinct tumor immune microenvironmental (TIME) landscapes drive divergent immunotherapy responses in glioblastoma

2025-10-19

Abstract excerpt

<h4>Background</h4> Immunotherapies have improved outcomes in many cancers but show limited efficacy in glioblastoma (GBM). This study aimed to determine whether immunotherapy could be tailored to GBM by functional subtyping of vascular-immune landscapes. <h4>Methods</h4> We employed single-cell RNA sequencing, multiplex immunohistochemistry to characterize three distinct TIME subtypes in human and murine GBMs....

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Identifiers and source

Literature Corpus work: c9092bdf-2166-504c-9936-de328b882e0f
DOI: 10.1101/2025.10.18.683203

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