Article

Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model

2025-05-12

Abstract excerpt

Multiple sclerosis (MS) is characterized by chronic inflammatory demyelination involving complex interplay between the central nervous and immune systems. Neuroinflammation triggers cellular reorganization requiring l -serine for sustained syntheses of membrane lipids and nucleic acids, whereas it causes aberrant glutamatergic neurotransmission involving d -serine. However, significance of serine metabolism in M...

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Literature Corpus work: ff4ad6b6-7625-5358-bbc6-14771b25f5df
DOI: 10.1101/2025.05.07.652561

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