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D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?

5 Feb 2019

Abstract excerpt

D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of many preclinical studies to ascertain the nature of its metabolism, its regional and cellular distribution in the brain, its physiological functions and its possible clinical relevance. The enzymes involved in its formation and catabolism are serine racemase (SR) and D-amino acid oxidase (DAAO), respectively, and...

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PMID: 30787885
DOI: 10.3389/fpsyt.2019.00025

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