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The Role of D-Amino Acids in Alzheimer’s Disease

2 Feb 2021

Abstract excerpt

Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the central nervous system is mediated by glutamate and its receptors are involved in synaptic plasticity. The N-methyl-D-aspartate (NMDA) receptors, which require the agonist glutamate and a coagonist such as glycine or the D-enantiomer of...

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PMID: 33554911
DOI: 10.3233/jad-201217

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